E0656

ER-27319

≥98% (HPLC), solid

• Synonym(s): 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate
• Empirical Formula (Hill Notation): C₂₀H₂₂N₂O₅
• CAS Number: 201010-95-9
• Molecular Weight: 370.40
• Número MDL: MFCD07784502
• ID de substância PubChem: 24724472
• NACRES: NA.77

Properties

• Nível de qualidade: 100
• teor: ≥98% (HPLC)
• forma: solid
• solubilidade: DMSO: 28 mg/mL
• temperatura de armazenamento: 2-8°C
• SMILES string: OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C
• InChI: 1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)
• InChI key: IIELZHYJYZBSGG-UHFFFAOYSA-N

Description

Embalagem

5 mg in glass bottle

25 mg in poly bottle

Ações bioquímicas/fisiológicas

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302 + H312
• Declarações de precaução: P264 - P270 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 1
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable