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E1024

Sigma-Aldrich

Estradiol

meets USP testing specifications

Sinônimo(s):

β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

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1 G
R$ 346,00
25 G
R$ 4.607,00
100 G
R$ 16.998,00

R$ 346,00

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1 G
R$ 346,00
25 G
R$ 4.607,00
100 G
R$ 16.998,00

About This Item

Fórmula empírica (Notação de Hill):
C18H24O2
Número CAS:
50-28-2
Peso molecular:
272.38
Beilstein:
1914275
Número CE:
200-023-8
Número MDL:
MFCD00003693
Código UNSPSC:
12352104
ID de substância PubChem:
24894380
NACRES:
NA.21

R$ 346,00

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Request a Bulk Order

Agency

USP/NF
meets USP testing specifications

Nível de qualidade

200

Formulário

powder

pf

176-180 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

cadeia de caracteres SMILES

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

chave InChI

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Informações sobre genes

human ... ESR1(2099) , ESR2(2100) , ESRRB(2103) , GPER(2852) , SERPINA6(866)
mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379)
rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

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Categorias relacionadas

Ações bioquímicas/fisiológicas

The major estrogen secreted by the premenopausal ovary.
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palavra indicadora

Danger

Frases de perigo

H351,H360FD,H362,H410

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000431853
0000431853
0000336259
0000336259
0000402372

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

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Sigma-Aldrich

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Estriol ≥97%

Sigma-Aldrich

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Progesterone ≥99%

Sigma-Aldrich

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Progesterone

β-Estradiol 17-acetate ≥99%

Sigma-Aldrich

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β-Estradiol 17-acetate

17β-Estradiol-2,3,4-13C3 solution ampule of 1 mL, Cerilliant®

Supelco

E-073

17β-Estradiol-2,3,4-13C3 solution

Martial Pré et al.
Plant physiology, 147(3), 1347-1357 (2008-05-10)
Plant defense against pathogens depends on the action of several endogenously produced hormones, including jasmonic acid (JA) and ethylene. In certain defense responses, JA and ethylene signaling pathways synergize to activate a specific set of defense genes. Here, we describe
Fiona C Baker et al.
Psychoneuroendocrinology, 60, 96-104 (2015-07-05)
The menopausal transition is marked by increased prevalence in disturbed sleep and insomnia, present in 40-60% of women, but evidence for a physiological basis for their sleep complaints is lacking. We aimed to quantify sleep disturbance and the underlying contribution
Agnete Overgaard et al.
Endocrinology, 155(10), 3945-3955 (2014-07-23)
Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
Yasushi Totoki et al.
Nature genetics, 46(12), 1267-1273 (2014-11-05)
Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503
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Questions

1–7 of 7 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Is product E1024 soluble in DMSO? If so, what is the recommended initial stock concentration to make?

    1 answer

    1. This product has not been tested for solubility in DMSO, however various sources report that it is soluble at 20 mg/mL.

      Helpful?

  4. What is the working range of Product E1024, Estradiol?

    1 answer

    1. For cell culture applications, the working range of this compound is 0.2 - 10 ng/mL.  For cell culture tested beta-estradiol, please refer to Sigma-Aldrich Prod. Nos. E2758 and E2257.

      Helpful?

  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  6. What is the solution stability of Product E1024, Estradiol?

    1 answer

    1. Since this material is air sensitive, it is best to prepare solutions fresh.

      Helpful?

  7. What is Product E1024, Estradiol, soluble in?

    1 answer

    1. It is soluble in ethanol, acetone, dioxane, and sparingly in vegetable oils.

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