Merck
All Photos(3)

E4642

Sigma-Aldrich

(±)-Epinephrine hydrochloride

Synonym(s):
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
Empirical Formula (Hill Notation):
C9H13NO3 · HCl
CAS Number:
Molecular Weight:
219.67
Número EC:
Número MDL:
ID de substância PubChem:

Nível de qualidade

200

solubilidade

H2O: 50 mg/mL

temperatura de armazenamento

2-8°C

SMILES string

OC(CNC)C1=CC=C(O)C(O)=C1.Cl

InChI

1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H

InChI key

ATADHKWKHYVBTJ-UHFFFAOYSA-N

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Descrição geral

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[1] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[2] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[3]

Aplicação

(±)-Epinephrine hydrochloride has been used:
  • in the induction of renalase expression in Human renal proximal tubular epithelial cells[4]
  • in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[5]
  • as a medium supplement for the stimulation of endothelial progenitor cells[6]

Embalagem

5, 25 g in glass bottle

Ações bioquímicas/fisiológicas

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[3] It is used in the treatment of acute anaphylaxis.[7] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[8]
Adrenergic receptor agonist.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificate of Analysis

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Certificate of Origin

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