E4876

17α-Ethynylestradiol

≥98%

• Synonym(s): 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol
• Empirical Formula (Hill Notation): C₂₀H₂₄O₂
• CAS Number: 57-63-6
• Molecular Weight: 296.40
• Beilstein: 2419975
• Número EC: 200-342-2
• Número MDL: MFCD00003690
• ID de substância PubChem: 24894585
• NACRES: NA.77

Properties

• fonte biológica: synthetic
• sterility: non-sterile
• teor: ≥98%
• forma: powder
• pf: 182-183 °C (lit.)
• solubilidade: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• enviado em: ambient
• temperatura de armazenamento: room temp
• SMILES string: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
• InChI key: BFPYWIDHMRZLRN-SLHNCBLASA-N
• Gene Information: human ... ESR1(2099) ; rat ... Afp(24177) , Esr1(24890) , Shbg(24775)

Description

Descrição geral

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

Aplicação

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.

Embalagem

100 mg in glass bottle

1, 10 g in glass bottle

Ações bioquímicas/fisiológicas

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

Safety Information

• Pictogramas: GHS07,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302 - H350 - H410
• Declarações de precaução: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1B
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges