E8875

β-Estradiol

≥98%

• Synonym(s): 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Empirical Formula (Hill Notation): C₁₈H₂₄O₂
• CAS Number: 50-28-2
• Molecular Weight: 272.38
• Beilstein: 1914275
• Número EC: 200-023-8
• Número MDL: MFCD00003693
• ID de substância PubChem: 24278426
• NACRES: NA.77

Properties

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• sterility: non-sterile
• teor: ≥98%
• forma: powder
• technique(s): cell culture | mammalian: suitable
• pf: 176-180 °C (lit.)
• solubilidade: ethanol: 50 mg/mL, clear, colorless
• enviado em: ambient
• temperatura de armazenamento: room temp
• SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Gene Information: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , GPER(2852) , SERPINA6(866) ; mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379) ; rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

Description

Aplicação

β-Estradiol has been used:

• for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
• as a supplement in in vitro maturation medium (IVM), which is used as a control medium
• in estrogen-induction assay

Embalagem

250 mg in glass bottle

1, 5, 25, 100 g in glass bottle

Ações bioquímicas/fisiológicas

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictogramas: GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H351 - H360FD - H362 - H410
• Declarações de precaução: P201 - P202 - P260 - P263 - P273 - P308 + P313
• Classificações de perigo: Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• Código de classe de armazenamento: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges