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ED2SC

Sigma-Aldrich

Ethylenediaminetetraacetic acid calcium disodium salt

Sinônimo(s):
EDTA calcium disodium salt, Edathamil, (Ethylenedinitrilo)tetraacetic acid calcium disodium salt
Fórmula linear:
C10H12N2O8CaNa2
Número CAS:
Peso molecular:
374.27
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

200

fonte biológica

synthetic

teor

97.0-102.0% (titration)

forma

powder

solubilidade

water: 1.6 g/10 mL, clear, colorless to faintly yellow

temperatura de armazenamento

room temp

SMILES string

[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4

InChI key

SHWNNYZBHZIQQV-UHFFFAOYSA-J

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Aplicação

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors. As this form is already chelated with Ca2+, it is selective for divalent cations with greater affinity for EDTA, which it will exchange for Ca2+.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 2

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

Bénédicte Gnangnon et al.
Bio-protocol, 10(11), e3647-e3647 (2021-03-05)
The study of host/pathogen interactions at the cellular level during Plasmodium intra-erythrocytic cycle requires differential extraction techniques aiming to analyze the different compartments of the infected cell. Various protocols have been proposed in the literature to study specific compartments and/or
Matthew A Walker et al.
JCI insight, 6(3) (2021-02-09)
A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively correlated with the
Evaluation of the Trial to Assess Chelation Therapy (TACT): the scientific process, peer review, and editorial scrutiny.
Howard Bauchner et al.
JAMA, 309(12), 1291-1292 (2013-03-28)
Xiaowei Yang et al.
Biochimica et biophysica acta, 1830(8), 4179-4188 (2013-05-04)
The major cytoskeletal protein of most cells is actin, which polymerizes to form actin filaments (F-actin). Each actin monomer (G-actin) contains a divalent alkaline earth metal ion (in vivo Mg(2+); in vitro usually Ca(2+)) as a cofactor that is crucial
Chelation therapy and cardiovascular outcomes.
John A Bittl
JAMA, 310(4), 430-431 (2013-08-07)

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