Merck
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F7301

Sigma-Aldrich

Fibroblast Growth Factor-18 human

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):
FGF-18
Número EC:
Número MDL:
NACRES:
NA.32

Nível de qualidade

200

fonte biológica

human

recombinante

expressed in E. coli

teor

>95% (SDS-PAGE and HPLC)

forma

lyophilized powder

potência

≤0.5 ng/mL

peso molecular

predicted mol wt 21.2 kDa

embalagem

pkg of 25 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

endotoxin, tested

nº de adesão UniProt

temperatura de armazenamento

−20°C

Gene Information

human ... FGF18(8817)

Descrição geral

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.

Ações bioquímicas/fisiológicas

FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.
FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.

forma física

Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.

Nota de análise

The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 2

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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SDS

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