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F8758

Sigma-Aldrich

Folic acid

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sinônimo(s):
Pterylmonoglutamic acid, PteGlu, Vitamin M, Pteroyl-L-glutamic acid
Empirical Formula (Hill Notation):
C19H19N7O6
Número CAS:
Peso molecular:
441.40
Beilstein:
100781
Número EC:
Número MDL:
eCl@ss:
34058014
ID de substância PubChem:
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

synthetic

linha de produto

BioReagent

teor

≥97%

forma

powder

peso molecular

Mw 441.40 g/mol

aplicação(ões)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

cor

dark yellow

solubilidade

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange

temperatura de armazenamento

room temp

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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Categorias relacionadas

Descrição geral

Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).

Aplicação

Folic acid has been used:
  • to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
  • in cells and treatments
  • in perforin gene targeting using the CRISPR/Cas gene editing approach

Embalagem

5, 25 g in glass bottle

Ações bioquímicas/fisiológicas

A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

Outras notas

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8758.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Storage Class Code

11 - Combustible Solids

WGK Alemanha

WGK 1

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Certificado de origem

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of folic acid (Product No. F8758)?

    Product No. F8758 is soluble in 1 M NaOH (50 mg/mL). The free acid is only slightly soluble in water (0.01 mg/mL at 0 °C), and is insoluble in aqueous solutions below pH 5. It is soluble in sodium bicarbonate or sodium hydroxide solutions.

  6. What is the stability of folic acid (Product No. F8758) once in solution?  

    This product is photolabile and is inactivated by UV light. Alkaline solutions are reasonably stable in the dark, but heating will destroy both alkaline and acidic solutions.

  7. Is Product No. F8758, Folic Acid, tested for endotoxins?  

    No, Product No. F8758 has not been tested for endotoxins. This product has, however, been tested for use in mammalian cell culture and insect cell culture.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study
Li Z, et al.
International Journal of Epidemiology, 43(4), 1132-1139 (2014)
Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway
Wang Y, et al.
PloS one, 11(3), e0152599-e0152599 (2016)
Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2
Sevim H, et al.
Stem Cell Research & Therapy, 9(1), 198-198 (2018)
Folic acid handling by the human gut: implications for food fortification and supplementation
Patanwala I, et al.
American Journal of Clinical Nutrition, 100(2), 593-599 (2014)
The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
Ducommun P, et al.
Cytotechnology, 37(2), 65-73 (2001)

Artigos

Folic Acid and Tetrahydrofolates in Cell Culture

Importance and uses of folic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures. Folic acid and its reduced derivative(s), such as folinic acid, are an essential water soluble vitamins added to virtually all cell culture media.

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