Gentamicin solution

50 mg/mL in deionized water, liquid, 0.1 μm filtered, BioReagent, suitable for cell culture

Número CAS:
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Nível de qualidade


fonte biológica



0.1 μm filtered

linha de produto





50-60 mg per mL


50 mg/mL in deionized water


cell culture | mammalian: suitable


endotoxin, tested


colorless to light yellow


1.000 g/cm3

Modo de ação

protein synthesis | interferes

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

temperatura de armazenamento


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Descrição geral

Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.


Gentamicin solution has been used as an antibiotic component in eukaryotic cell culture and bacterial culture.
Gentamicin sulfate is a broad-spectrum antibiotic used as a selection agent (gentamicin-resistance gene) in molecular biology and cell culture applications. This product is formulated to contain 50 mg/mL Gentamicin in deionized water and is recommended for use in eukaryotic cell culture at a volume of 1 milliliter per liter.
Gentamicin sulfate solution has been used as a component of different types of culture media.

Ações bioquímicas/fisiológicas

Gentamicin is recommended for treating sepsis during emergency treatment. It is an alternate to ceftriaxone for treating genital infection.
Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.

Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.


Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.


The product is stable at 37° for 5 days and is stored at 2-8°C.


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Frases de perigo


Skin Sens. 1


10 - Combustible liquids

WGK Alemanha


Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise

Certificado de origem

Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial
Ross JDC, et al.
Lancet, e0210012-e0210012 (2019)
Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department
Cobussen M, et al.
PLoS ONE, 14(1), e0210012-e0210012 (2019)
Ruochan Chen et al.
Frontiers in immunology, 10, 1904-1904 (2019-08-24)
Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that...
David E Swayne
International journal of food microbiology, 108(2), 268-271 (2006-02-17)
A precise, reproducible microassay was developed to measure thermal inactivation of high pathogenicity avian influenza (HPAI) virus in chicken meat. Small pieces of breast or thigh meat (0.05 g) from chickens infected with A/chicken/Pennsylvania/1370/1983 (H5N2) (PA/83) or A/chicken/Korea/ES/2003 (H5N1) (Korea/03)...
Rui Kang et al.
Cell host & microbe, 24(1), 97-108 (2018-06-26)
Sepsis is a life-threatening condition caused by pathogen infection and associated with pyroptosis. Pyroptosis occurs upon activation of proinflammatory caspases and their subsequent cleavage of gasdermin D (GSDMD), resulting in GSDMD N-terminal fragments that form membrane pores to induce cell...
Human renal proximal tubule epithelial cells (RPTECs) are commonly used to predict human renal drug permeability and to investigate drug efflux. We have generated transporter knockout (KO) cell lines using CompoZr® Zinc Finger Nuclease (ZFN) technology in a proprietary renal proximal tubule epithelial cell line.
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