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G 418 disulfate salt solution

50 mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture

Antibiotic G418
Empirical Formula (Hill Notation):
C20H40N4O10 · 2H2SO4
Número CAS:
Peso molecular:
Número MDL:
ID de substância PubChem:

Nível de qualidade


fonte biológica

Micromonospora echinospora


0.1 μm filtered

linha de produto





50-60 mg per mL

peso molecular



pkg of 10 and 100 mL


50 mg/mL in H2O


cell culture | mammalian: suitable


endotoxin, tested




H2O: 50 mg/mL, clear

espectro de atividade do antibiótico


Modo de ação

protein synthesis | interferes

temperatura de armazenamento


SMILES string




InChI key


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Descrição geral

Chemical structure: aminoglycoside


G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

Ações bioquímicas/fisiológicas

Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.

Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.


The product is stable for two years when stored at 2-8°C.


Health hazard

Palavra indicadora


Frases de perigo

Classificações de perigo

Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

12 - Non Combustible Liquids



Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

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Transcription activation by distal enhancers is essential for cell-fate specification and maintenance of cellular identities. How long-range gene regulation is physically achieved, especially within complex regulatory landscapes of non-binary enhancer-promoter configurations, remains elusive. Recent nanoscopy advances have quantitatively linked promoter
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The methylotrophic yeast, Pichia pastoris, is widely used as a host organism for the expression of heterologous proteins. Currently, the Zeocin and blasticidin resistance genes are the only dominant selectable markers that can be used for primary selection of transformants.
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Frontiers in immunology, 11, 774-774 (2020-05-21)
We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples. In order to capture the activation products iC3b and C3dg in a specific and
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Aberrant regulation of programmed cell death (PCD) has been tied to an array of human pathologies ranging from cancers to autoimmune disorders to diverse forms of neurodegeneration. Pharmacologic modulation of PCD signalling is therefore of central interest to a number
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