H0888

Hydrocortisone

BioReagent, suitable for cell culture

• Synonym(s): 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Empirical Formula (Hill Notation): C₂₁H₃₀O₅
• CAS Number: 50-23-7
• Molecular Weight: 362.46
• Beilstein: 1354819
• Número EC: 200-020-1
• Número MDL: MFCD00011654
• ID de substância PubChem: 24895415
• NACRES: NA.77

Properties

• fonte biológica: plant (wild yam)
• Nível de qualidade: 200
• linha de produto: BioReagent
• teor: ≥98%
• forma: powder
• technique(s): cell culture | mammalian: suitable
• pf: 211-214 °C (lit.)
• solubilidade: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
• enviado em: ambient
• temperatura de armazenamento: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) ; rat ... Ar(24208) , Nr3c1(24413)

Description

Aplicação

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

Embalagem

1, 5, 10, 25 g

Ações bioquímicas/fisiológicas

Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

forma física

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstituição

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

Safety Information

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360Df - H373
• Declarações de precaução: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1A - STOT RE 2
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges