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H4652

Sigma-Aldrich

HMG-1 human

lyophilized powder, ≥90% (SDS-PAGE), Histidine-tagged, recombinant, expressed in E. coli

Synonym(s):
Amphoterin, HMGB1, High-Mobility-Group protein
Número MDL:
ID de substância PubChem:

Nível de qualidade

200

recombinante

expressed in E. coli

teor

≥90% (SDS-PAGE)

forma

lyophilized powder

peso molecular

25 kDa (215 amino acids; comprises two homologous HMG boxes, rich in basic amino acids, and an acidic tail at the carboxy-terminus)

nº de adesão UniProt

enviado em

dry ice

temperatura de armazenamento

−20°C

SMILES string

COC(=O)CCCCCCCCCCCCCCO

Gene Information

human ... HMGB1(3146)

Descrição geral

HMG-1 (high mobility group protein) is a nuclear protein of molecular weight 30kDa. It is secreted from macrophages, monocytes and necrotic cells. It is ubiquitously expressed. The protein has basic HMG (high mobility group) box domains and an acidic carboxyl-terminus.

Aplicação

HMG-1 (high-mobility-group protein) human has been used:
  • to prepare a standard curve for measuring HMG1 using ELISA (enzyme-linked immunosorbent assay) test
  • to study the apoptotic ratios of Lewis cells in presence of exogenous HMG-1
  • to study the changes in Th (T helper)-17 cell expansion in the presence of HMG-1 under in vitro conditions
  • for the migration assay of GM7373 cells

Ações bioquímicas/fisiológicas

HMG-1 (high mobility group protein) is a non-histone chromosomal protein, which promotes the sequence specific DNA attachment of proteins. HMG1 binds DNA in a non-sequence specific manner. It is involved in DNA replication, transcription and repair. In addition, it is up-regulated in cancers and is associated with cellular growth, vasculogenesis and apoptosis regulation. In the presence of infection or injury, HMG1 is secreted and mediates inflammation. It is associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).

forma física

Lyophilized powder containing HEPES buffer salts, pH 7.8, NaCl, EDTA, Triton X-100, Leupeptin and AEBSF.

Nota de análise

Tested in DNA retardation assay

Pictogramas

CorrosionEnvironment

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Quotes and Ordering

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