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H7291

Sigma-Aldrich

Interleukin-4 human

potency:, IL-4, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Número MDL:
NACRES:
NA.77

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in HEK 293 cells

teor

>95% (SDS-PAGE)

forma

lyophilized powder

potência

≤0.6 ng/mL EC50

qualidade

endotoxin tested

peso molecular

dimer 14-19 kDa (glycosylated)

embalagem

pkg of 1 mg
pkg of 10 μg
pkg of 100 μg

manufacturer/tradename

HumanZyme

technique(s)

cell culture | mammalian: suitable

Impurezas

<1 EU/μg

nº de adesão UniProt

temperatura de armazenamento

−20°C

Gene Information

human ... IL4(3565)

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Descrição geral

Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.

Embalagem

10 μg in poly bottle

Ações bioquímicas/fisiológicas

Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.

forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de preparo

HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Nota de análise

The specific activity was determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Informações legais

HumanKine is a registered trademark of Proteintech Group, Inc.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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