Merck
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I0516

Sigma-Aldrich

Insulin solution from bovine pancreas

10 mg/mL insulin in 25  mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

Synonym(s):
Bovine insulin, Cell culture grade insulin
CAS Number:
Número MDL:
NACRES:
NA.77

esterilidade

sterile-filtered

Nível de qualidade

400

linha de produto

BioReagent

forma

solution

concentração

10 mg/mL insulin in 25  mM HEPES, pH 8.2

technique(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

pH

7.9-8.5

nº de adesão UniProt

enviado em

ambient

temperatura de armazenamento

2-8°C

InChI

1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1

InChI key

XYPANFGXFLOTDK-CJLNJPJHSA-N

Gene Information

bovine ... INS(280829)
cow ... INS(280829)

Related Categories

Aplicação

Insulin solution from bovine pancreas has been used:
  • to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifers
  • to study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explants
  • to study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro

Ações bioquímicas/fisiológicas

Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

forma física

stable 2-8 °C

Código de classe de armazenamento

12 - Non Combustible Liquids

WGK

WGK 2

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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