I0634

Sigma-Aldrich

Ionomycin calcium salt from Streptomyces conglobatus

powder, ≥98% (HPLC)

Empirical Formula (Hill Notation):
C41H70CaO9
Número CAS:
Peso molecular:
747.07
Beilstein/REAXYS Number:
1416163
Número MDL:
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

300

teor

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated
protect from light

cor

white to off-white

solubilidade

DMSO: 10 mg/mL
ethanol: soluble

Modo de ação

cell membrane | interferes

espectro de atividade do antibiótico

Gram-positive bacteria

temperatura de armazenamento

2-8°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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Categorias relacionadas

Embalagem

1, 5 mg in glass bottle

Ações bioquímicas/fisiológicas

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.

Nota de preparo

Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

hazcat

Acute Tox. 4 Oral

storage_class_code

11 - Combustible Solids

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

Sanne P Smeekens et al.
International immunology, 22(11), 889-895 (2010-11-10)
The fungus Candida albicans is a potent inducer of the T(h)17 response. Prostaglandin E2 (PGE2) is a strong pro-inflammatory mediator, which has proven to be essential for the T(h)17 response. In this study, we have investigated the role of PGE2...
Colin D H Ratcliffe et al.
The Journal of cell biology, 218(1), 285-298 (2018-11-09)
Differential inclusion or skipping of microexons is an increasingly recognized class of alternative splicing events. However, the functional significance of microexons and their contribution to signaling diversity is poorly understood. The Met receptor tyrosine kinase (RTK) modulates invasive growth and...
Li Li et al.
Immunobiology, 216(4), 477-484 (2010-10-19)
Most of the studies evaluating the function of tuberculosis (TB)-specific T cells were only based on the ability to produce cytokines, which may not fully reflect the function of T cells. In the present study, we confirmed that Bacille Calmette...
Yinxiang Wei et al.
Cellular & molecular immunology, 16(6), 580-589 (2018-05-31)
Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which...
Birgitta Lindqvist et al.
PLoS pathogens, 16(1), e1008264-e1008264 (2020-01-31)
Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous reservoir that at any time can reactivate the integrated HIV-1. Here we confirmed that latently...

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