I127

ICI 118,551 hydrochloride

≥98% (HPLC), powder

• Synonym(s): (2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₇NO₂ · HCl
• CAS Number: 72795-01-8
• Molecular Weight: 313.86
• Número MDL: MFCD00153812
• ID de substância PubChem: 24277782
• NACRES: NA.77

Properties

• Nível de qualidade: 100
• teor: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white
• solubilidade: H₂O: >10 mg/mL
• SMILES string: Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
• InChI: 1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
• InChI key: KBXMBGWSOLBOQM-LINSIKMZSA-N
• Gene Information: human ... ADRB2(154)

Description

Aplicação

ICI 118,551 hydrochloride has been used:

• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Embalagem

5, 25 mg in glass bottle

Ações bioquímicas/fisiológicas

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

ICI 118,551 hydrochloride is a highly selective β₂-adrenoceptor antagonist.

Características e benefícios

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Hygroscopic

Safety Information

• Código de classe de armazenamento: 13 - Non Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)