Merck
Todas as fotos(2)

Documentos

I1507

Sigma-Aldrich

Insulina

≥95% (HPLC), semisynthetic, powder

Empirical Formula (Hill Notation):
C257H383N65O77S6
Número CAS:
Peso molecular:
5807.57
Número EC:
Número MDL:
NACRES:
NA.83

fonte biológica

semisynthetic

Nível de qualidade

esterilidade

non-sterile

Ensaio

≥95% (HPLC)

forma

powder

concentração

>75%

technique(s)

cell culture | mammalian: suitable

solubilidade

0.01 M HCl: 0.5 mg/mL, clear to slightly hazy, colorless

nº de adesão UniProt

enviado em

ambient

temperatura de armazenamento

−20°C

SMILES string

CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CNC=N2)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Gene Information

human ... INS(3630)

Procurando produtos similares? Visit Guia de comparação de produtos

Categorias relacionadas

Comparar Itens Semelhantes

Ver Comparação Total

Show Differences

1 of 4

Este Item
I353611376497001I2643
Insulin human ≥95% (HPLC), semisynthetic, powder

Sigma-Aldrich

I1507

Insulin human

Sigma-Aldrich

Sigma-Aldrich

I3536

Insulin human

Insulin, human recombinant (yeast)

Roche

11376497001

Insulin, human

Insulin human recombinant, expressed in yeast (proprietary host)

Sigma-Aldrich

I2643

Insulin human

sterility

non-sterile

sterility

γ-irradiated

sterility

non-sterile; 0.2 μm filtered

sterility

non-sterile

assay

≥95% (HPLC)

assay

-

assay

>98% (SDS-PAGE)

assay

≥98% (HPLC)

form

powder

form

lyophilized powder

form

lyophilized (clear, colorless solution after reconstitution)

form

powder

concentration

>75%

concentration

-

concentration

-

concentration

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Descrição geral

Research area: Cell Signaling

Insulin binds to the receptors of target cells in the liver, skeletal muscle and fat, b cells, brain cells, and many other cells. The insulin gene is located on human chromosome 11p15.5.

Aplicação

Insulin human has been used:
  • in artificial cerebrospinal fluid (aCSF) to study the effect of preoptic area administration of insulin on core body temperature (CBT) in mice
  • in contact-mode scanning probe electrospray ionization (SPESI) to study the effect of substrate vibration on ionization efficiency
  • as a component of adipocyte differentiation media

Ações bioquímicas/fisiológicas

Hormônio polipeptídico de duas cadeias produzido pelas células β das ilhotas pancreáticas. Seu peso molecular é de cerca de 5800 Da. As cadeias α e β são ligadas por duas pontes dissulfeto entre as cadeias. A cadeia α contém uma ponte dissulfeto dentro da cadeia. A insulina regula a captação celular, o uso e o armazenamento de glicose, aminoácidos e ácidos graxos, além de inibir a quebra de glicogênio, proteínas e gordura.
Insulin is important to maintain normal blood sugar levels. Insulin deficiency is associated with diabetes mellitus.
Insulin signaling is associated with two important pathways namely: phosphatidylinositol 3-kinase (PI3K, a lipid kinase)/AKT (also known as PKB or protein kinase B) pathway and the Raf/Ras/MEK/ MAPK (mitogen-activated protein kinase, also known as ERK or extracellular signal-regulated kinase) pathway. Insulin increases the metabolic pathways controlling glycogen synthesis, gene expression, DNA synthesis, and Na+/K+ pump. It inhibits metabolic pathways regulating apoptosis and autophagy.

Outras notas

InChI: 1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

Nota de preparo

Derived from porcine insulin

produto relacionado

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

WGK

nwg

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Os números dos produtos são combinados com os tamanhos/quantidades da embalagem quando exibidos no site (exemplo: T1503-25G). Por favor, certifique-se você insere APENAS o número do produto no campo Número do produto (Exemplo T1503).

Exemplo

T1503
Número do produto
-
25G
Tamanho/quantidade da embalagem

Exemplos adicionais:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

insira como1.000309185)

Está com problemas? Sinta-se à vontade para entrar em contato Assistência Técnica para obter assistência

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Produtos Aldrich

  • Se encontrar um número de lote como TO09019TO - insira o número do lote 09019TO sem as duas primeiras letras.

  • Se encontrar um número de lote com um código de preenchimento, como 05427ES-021 - insira o número do lote 05427ES sem o código de preenchimento -021.

  • Se encontrar um número de lote com um código de preenchimento como STBB0728K9 - digite o número do lote STBB0728 sem o código de preenchimento K9.

Não encontra o que está procurando?

Em alguns casos, um COA pode não estar disponível on-line. Se a sua pesquisa não encontrou o COA, você pode solicitar um.

Solicitar COA

Os clientes também visualizaram

Slide 1 of 6

1 of 6

Insulin from bovine pancreas ≥25 USP units/mg (HPLC), powder

Sigma-Aldrich

I5500

Insulin from bovine pancreas

vibrant-m

Y0001717

Insulin porcine for system suitability

Insulin from bovine pancreas Hybri-Max™, powder, suitable for hybridoma

Sigma-Aldrich

I4011

Insulin from bovine pancreas

The role of insulin-like growth factor 2 and its receptors in human tumors
Pavelic K, et al.
Molecular Medicine, 8(12), 771-780 (2002)
The Role of Melatonin Preconditioning on Survival of Bone Marrow-Derived Mesenchymal Stem Cells in Differentiation to Osteoblasts
Rafat A, et al.
Iranian Red Crescent Medical Journal (2018)
Dose-and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes
Yanting C, et al.
Journal of Dairy Science, 101(2), 1601-1615 (2018)
Lutein leads to a decrease of factor D secretion by cultured mature human adipocytes
Tian Y, et al.
Journal of Ophthalmology, 2015 (2015)
Manuel Sanchez-Alavez et al.
Diabetes, 59(1), 43-50 (2009-10-23)
Temperature and nutrient homeostasis are two interdependent components of energy balance regulated by distinct sets of hypothalamic neurons. The objective is to examine the role of the metabolic signal insulin in the control of core body temperature (CBT). The effect

Protocolos

Reversed-Phase HPLC Analysis of Insulin Variants and Analogs by UV and Mass Spectral Detection

Insulin is an approximately 6000 Da peptide hormone used to regulate the glucose concentration in blood. There are several different forms of insulin that are both natural and recombinant; the recombinant forms have been engineered to improve pharmacokinetic properties. A quick and reliable chromatographic technique was developed to identify and detect a mixture of insulin variants in an unknown sample.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica