Merck
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I3036

Sigma-Aldrich

Polyinosinic–polycytidylic acid potassium salt

γ-irradiated

Synonym(s):
Poly (I:C), Poly(I) • Poly(C)
CAS Number:
Número MDL:

Nível de qualidade

200

teor

≥99% (TLC)

composição

, 8-12% UV

temperatura de armazenamento

−20°C

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Ações bioquímicas/fisiológicas

Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.

Embalagem

Package size based on polynucleotide content

Outras notas

Double-stranded homopolymer.

forma física

10% Poly (I:C) with sodium chloride and sodium phosphate buffer salts

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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