Merck
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I4011

Sigma-Aldrich

Insulin from bovine pancreas

Hybri-Max, powder, suitable for hybridoma

Empirical Formula (Hill Notation):
C254H377N65O75S6
Número CAS:
Peso molecular:
5733.49
Número EC:
Número MDL:

Nível de qualidade

200

grau

Hybri-Max

forma

powder

potência

≥20 USP units per mg (dry basis)

technique(s)

cell culture | hybridoma: suitable

Impurezas

endotoxin, tested

solubilidade

acidified water, pH 2.0: 2 mg/mL

traços de cátion

Zn: ≤1.0% (dry basis)

nº de adesão UniProt

enviado em

ambient

temperatura de armazenamento

−20°C

InChI key

IXIBAKNTJSCKJM-BUBXBXGNSA-N

Gene Information

bovine ... INS(280829)
cow ... INS(280829)

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Categorias relacionadas

Descrição geral

The insulin gene is mapped to human chromosome 11p15.5.

Aplicação

Insulin from bovine pancreas was used during experimental design and treatments. Experimental animals (like cow) were infused with bovine insulin to decrease blood glucose to a constant level.
Insulin from bovine pancreas has been used in endometrium cell culture. It has also been used to perform insulin tolerance test and to study the effect of protein undernutrition in laying hens.

Embalagem

50, 100, 250, 500 mg in poly bottle

Ações bioquímicas/fisiológicas

Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. The biological effects of insulin are mediated by insulin receptor (glycoprotein) and it integrates major signaling pathways.
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Outras notas

InChI: 1S/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-167(94-139-52-60-145(324)61-53-139)226(365)282-153(68-75-186(258)328)217(356)289-160(86-121(4)5)221(360)284-157(73-80-198(342)343)219(358)301-173(100-189(261)331)233(372)297-169(96-141-56-64-147(326)65-57-141)229(368)308-182(241(380)303-175(253(393)394)102-191(263)333)115-398-396-113-180(212(351)270-106-193(335)277-152(71-78-196(338)339)215(354)280-150(50-41-83-268-254(264)265)210(349)269-107-194(336)278-165(92-137-45-35-31-36-46-137)225(364)296-166(93-138-47-37-32-38-48-138)228(367)298-170(97-142-58-66-148(327)67-59-142)236(375)318-206(135(28)323)251(390)319-84-42-51-185(319)244(383)285-151(49-39-40-82-255)213(352)276-134(27)252(391)392)310-248(387)202(128(18)19)315-234(373)163(89-124(10)11)291-227(366)168(95-140-54-62-146(325)63-55-140)295-222(361)159(85-120(2)3)288-207(346)132(25)274-214(353)156(72-79-197(340)341)286-245(384)201(127(16)17)314-235(374)164(90-125(12)13)292-231(370)172(99-144-105-267-119-273-144)300-237(376)176(109-320)279-195(337)108-271-211(350)179(112-395-397-114-181(309-243(183)382)240(379)275-133(26)208(347)304-178(111-322)239(378)316-203(129(20)21)249(388)311-184)306-224(363)162(88-123(8)9)290-230(369)171(98-143-104-266-118-272-143)299-218(357)154(69-76-187(259)329)283-232(371)174(101-190(262)332)302-247(386)200(126(14)15)313-209(348)149(257)91-136-43-33-30-34-44-136/h30-38,43-48,52-67,104-105,118-135,149-185,200-206,320-327H,29,39-42,49-51,68-103,106-117,255-257H2,1-28H3,(H2,258,328)(H2,259,329)(H2,260,330)(H2,261,331)(H2,262,332)(H2,263,333)(H,266,272)(H,267,273)(H,269,349)(H,270,351)(H,271,350)(H,274,353)(H,275,379)(H,276,352)(H,277,335)(H,278,336)(H,279,337)(H,280,354)(H,281,355)(H,282,365)(H,283,371)(H,284,360)(H,285,383)(H,286,384)(H,287,385)(H,288,346)(H,289,356)(H,290,369)(H,291,366)(H,292,370)(H,293,377)(H,294,362)(H,295,361)(H,296,364)(H,297,372)(H,298,367)(H,299,357)(H,300,376)(H,301,358)(H,302,386)(H,303,380)(H,304,347)(H,305,381)(H,306,363)(H,307,359)(H,308,368)(H,309,382)(H,310,387)(H,311,388)(H,312,334)(H,313,348)(H,314,374)(H,315,373)(H,316,378)(H,317,389)(H,318,375)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,391,392)(H,393,394)(H4,264,265,268)/t131-,132-,133-,134-,135+,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,200-,201-,202-,203-,204-,205-,206-/m0/s1

Informações legais

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Product Information Sheet

Quotes and Ordering

Effects of nutritional programing on growth and metabolism caused by albumen removal in an avian model
Willems E, et al.
The Journal of Endocrinology, 225(2), 89-100 (2015)
Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells
Tasak Y, et al.
Journal of Reproduction and Development, 56(2), 223-229 (2010)
M C M B Vernay et al.
Journal of dairy science, 95(5), 2540-2549 (2012-05-01)
The metabolic load during periods of high milk production in dairy cows causes a variety of changes of metabolite blood concentrations including dramatically decreased glucose levels. These changes supposedly impair the immune system. The goal of this study was, therefore
Expression of glucocorticoid receptor alpha and its regulation in the bovine endometrium: Possible role in cyclic prostaglandin F2alpha production
Kuse M, et al.
Journal of Reproduction and Development, 59(4), 346-352 (2013)
Human longevity and 11p15. 5: a study in 1321 centenarians
Lescai F, et al.
European Journal of Human Genetics, 17(11), 1515-1515 (2009)

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