I7018

3-Isobutyl-1-methylxanthine

BioUltra, ≥99%

• Synonym(s): 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
• Empirical Formula (Hill Notation): C₁₀H₁₄N₄O₂
• CAS Number: 28822-58-4
• Molecular Weight: 222.24
• Beilstein: 247859
• Número EC: 249-259-3
• Número MDL: MFCD00005584
• ID de substância PubChem: 24896107
• NACRES: NA.77

Properties

• linha de produto: BioUltra
• Nível de qualidade: 200
• teor: ≥99%
• Impurezas: <0.005% Phosphorus (P)
• resíduo de ignição: <0.1%
• pf: 200-201 °C (lit.)
• solubilidade: DMSO: soluble 1 M (with gentle warming)
• traços de ânion: sulfate (SO₄^2-): <0.05%
• traços de cátion: Al: <0.0005%; Ca: <0.005%; Cu: <0.0005%; Fe: <0.005%; K: <0.05%; Mg: <0.005%; NH₄⁺: <0.05%; Na: <0.005%; Pb: <0.001%; Zn: <0.0005%
• temperatura de armazenamento: −20°C
• SMILES string: CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12
• InChI: 1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
• InChI key: APIXJSLKIYYUKG-UHFFFAOYSA-N
• Gene Information: rat ... Adora1(29290) , Adora2a(25369)

Description

Aplicação

3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:

• for adipogenic differentiation
• in tissue culture
• 3T3-L1 preadipocyte differentiation(

Ações bioquímicas/fisiológicas

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

Características e benefícios

• Trace element testing by ICP
• ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content
• Ion chromatography testing for trace ammonium content

Safety Information

• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves