Merck
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I7908

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Sinônimo(s):
T-cell growth factor, Interleukin-2, IL-2
Número MDL:
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

human

recombinante

expressed in Pichia pastoris

teor

≥98% (SDS-PAGE and HPLC)

forma

lyophilized powder

peso molecular

predicted mol wt ~15 kDa

embalagem

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

enviado em

dry ice

temperatura de armazenamento

−20°C

Gene Information

human ... IL2(3558)

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Categorias relacionadas

Aplicação

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Ações bioquímicas/fisiológicas

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

forma física

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Nota de análise

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

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Certificado de origem

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Quotes and Ordering

TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)
Nader Bayda et al.
Cancers, 13(4) (2021-02-10)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We
Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
The main function of IL-2 is to promote the development of T regulatory cells
Malek, Th, et al.
Journal of Leukocyte Biology, 74(6) (2003)
Fang Wang et al.
Journal of cellular and molecular medicine, 25(21), 10257-10267 (2021-10-22)
Oral lichen planus (OLP) is a T cell-mediated immunoinflammatory disease. Glycolysis plays an essential role in T-cell immune responses. Blocking glycolytic pathway in activated T cells represents a therapeutic strategy for restraint of immunologic process in autoimmune disorders. 2-Deoxy-D-glucose (2-DG)

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