Merck
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L2515

Sigma-Aldrich

Lipoteichoic acid from Staphylococcus aureus

bacterial cell wall polymer

CAS Number:
Número MDL:
NACRES:
NA.25

fonte biológica

Staphylococcus aureus

Nível de qualidade

200

forma

lyophilized powder

grupo funcional

phospholipid

enviado em

ambient

temperatura de armazenamento

2-8°C

Descrição geral

Lipoteichoic acid (LTA) is a linear polymer of phosphodiester-linked glycerol phosphate covalently bound to a lipid. The C2 position on the glycerol-phosphate is usually glycosylated or D-alanylated. LTA is amphipathic due to the presence of the negatively charged backbone of glycerol phosphate and the hydrophobic lipid. The lipid portion is bound hydrophobically to the cell membrane, whereas the polyglycerol phosphate portion extends into the cell wall.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.[1]

Aplicação

Lipoteichoic acid from Staphylococcus aureus has been used:
  • to investigate the binding properties of SpHyastatin to lipopolysaccharides and lipoteichoic acid using enzyme-linked immunosorbent assay (ELISA)
  • to measure the interleukin (IL-6) produced in splenocytes using a sandwich ELISA
  • as a toll-like receptor 2/6 (TLR2/6) agonist to explore its potential to induce tumoricidal M1 macrophage phenotype

Embalagem

5, 10, 25 mg in glass bottle

Ações bioquímicas/fisiológicas

Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a complex component of the cell walls of Gram-positive bacteria that are implicated in a wide range of cellular processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of Gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity, and functions versus other bacterial LTAs.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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