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L9133

Sigma-Aldrich

Leucine Enkephalin acetate salt hydrate

≥95% (HPLC)

Empirical Formula (Hill Notation):
C28H37N5O7 · xC2H4O2 · yH2O
Peso molecular:
555.62 (anhydrous free base basis)
Número MDL:
eCl@ss:
32160409
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

Ensaio

≥95% (HPLC)

temperatura de armazenamento

−20°C

SMILES string

O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1

InChI key

QKDIOZBQOQJXFR-XQCXOTTHSA-N

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Este Item
M6638T0675E7131
Leucine Enkephalin acetate salt hydrate ≥95% (HPLC)

Sigma-Aldrich

L9133

Leucine Enkephalin acetate salt hydrate

[Met5]Enkephalin acetate salt hydrate ≥95.0% (HPLC), powder

Sigma-Aldrich

M6638

[Met5]Enkephalin acetate salt hydrate

[D-Ala2]-Deltorphin II ≥97% (HPLC)

Sigma-Aldrich

T0675

[D-Ala2]-Deltorphin II

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Gene Information

human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)

Gene Information

human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprd1(18386), Oprm1(18390)
rat ... Oprd1(24613), Oprm1(25601)

Gene Information

human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu

Descrição geral

Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues. Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans. It is an endogenous opioid neurotransmitter/neuromodulator localized in brain parallels and in δ receptors.

Aplicação

Leucine Enkephalin acetate salt hydrate has been used in the calibration of the Q-Tof Micro hybrid, triple quadrupole-orthogonal acceleration time of flight (TOF) instrument in single-stage TOF mode. It has also been used to perform the calibration of mass spectrometry. It has also been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.

Ações bioquímicas/fisiológicas

Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites. It might also play a role as neurotransmitter agent at morphine-sensitive synapses. Leucine Enkephalin is also associated with pain regulation. LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion. LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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Dynorphin A porcine ≥95% (HPLC)

Sigma-Aldrich

D8147

Dynorphin A porcine

β-Endorphin rat ≥97% (HPLC)

Sigma-Aldrich

E1142

β-Endorphin rat

Met-Arg-Phe-Ala acetate salt ≥90% (HPLC)

Sigma-Aldrich

M1170

Met-Arg-Phe-Ala acetate salt

Bradykinin acetate salt analytical standard

Supelco

90834

Bradykinin acetate salt

Thymopentin ≥97% (HPLC)

Sigma-Aldrich

T8806

Thymopentin

β-Endorphin human ≥95% (HPLC)

Sigma-Aldrich

E6261

β-Endorphin human

Bradykinin acetate salt powder, ≥98% (HPLC)

Sigma-Aldrich

B3259

Bradykinin acetate salt

Substance P acetate salt hydrate ≥95% (HPLC), powder

Sigma-Aldrich

S6883

Substance P acetate salt hydrate

Pattern of distribution of neuropeptides in the camel lacrimal gland.
Adeghate E
Neuropeptides, 30(6), 566-571 (1996)
An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.
Thiphom S
Analytical Methods : Advancing Methods and Applications, 4(11), 3772-3778 (2012)
S R George et al.
The Journal of biological chemistry, 275(34), 26128-26135 (2000-06-08)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may interact with each
A P Sayani et al.
Journal of pharmaceutical sciences, 82(11), 1179-1185 (1993-11-01)
Leucine enkephalin (Tyr-Gly-Gly-Phe-Leu; Leu-Enk) is a naturally occurring peptide that has been shown to have pain modulating properties. To evaluate the feasibility of using various absorptive mucosae as a route of systemic delivery, the stability of Leu-Enk and the effect
J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by

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