The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.
LO4100
LOPAC®1280 - Pequena escala
Sinônimo(s):
Biblioteca de compostos farmacologicamente ativos - pequena escala
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Estamos aqui para ajudarFormulário
liquid
Nível de qualidade
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
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Categorias relacionadas
Descrição geral
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.[1]
Aplicação
LOPAC® 1280 - Small Scale has been used:
- in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis[2][3]
- for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay[1]
- for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors[4]
Características e benefícios
Arquivo SDFile fornecido para montar um banco de dados com:
- Estrutura
- Nome primário
- Nome secundário
- Atividade farmacológica
- Número do produto
- Posição na estante
Inclui as moléculas semelhantes a medicamentos mais modernas nos campos de sinalização celular e neurociência:
- Apoptose
- Proteínas G e nucleotídeos cíclicos
- Regulação e expressão gênica
- Canais iônicos
- Sinalização de lipídios
- Resistência a múltiplos medicamentos
- Neurotransmissão
- Fosforilação
Outras notas
For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.
Informações legais
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
Palavra indicadora
Danger
Declarações de precaução
Classificações de perigo
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Ponto de fulgor (°F)
188.6 °F
Ponto de fulgor (°C)
87 °C
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Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a
Martin Michael Peter Schulz et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), E2665-E2674 (2012-09-06)
Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisition and
Artigos
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
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What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?
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What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?
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The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280
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Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?
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There is no CAS number list available.
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What is the difference between the LOPAC1280 Products LO4100 and LO4200?
1 answer-
These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?
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The information is available in the datasheet of a similar product LO1280.
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 US approved?
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About 30% of the collection is made up of drugs approved for use in the US.
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?
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Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.
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Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?
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Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at [email protected] or 1800-325-5832.
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