Merck
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M0252

Sigma-Aldrich

Methylglyoxal solution

~40% in H2O

Synonym(s):
Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
Linear Formula:
CH3COCHO
CAS Number:
Molecular Weight:
72.06
Beilstein:
906750
Número MDL:
ID de substância PubChem:
NACRES:
NA.32

teor

~40% (enzymatic)

Nível de qualidade

200

forma

liquid

concentração

~40% in H2O

densidade

1.17 g/mL at 25 °C (lit.)

temperatura de armazenamento

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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Descrição geral

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Aplicação

Methylglyoxal solution has been used:
  • to assess glyoxalase 1 (GLO1) enzymatic activity
  • as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
  • to regulate anxiety like behavior in mice
  • to induce peritoneal fibrosis in rats
  • to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
  • for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

Palavra indicadora

Danger

Classificações de perigo

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Código de classe de armazenamento

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificate of Analysis

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Certificate of Origin

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