Merck
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M2650

Sigma-Aldrich

Anti-Mouse IgG (Fc specific) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Número MDL:
NACRES:
NA.46

fonte biológica

goat

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

forma

buffered aqueous solution

technique(s)

indirect ELISA: 1:15,000

enviado em

dry ice

temperatura de armazenamento

−20°C

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Este Item
A9917M5899M6898
conjugate

unconjugated

conjugate

peroxidase conjugate

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

whole antiserum

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

-

form

buffered aqueous solution

technique(s)

indirect ELISA: 1:15,000

technique(s)

direct ELISA: 1:60,000, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:150, western blot: 1:80,000-1:160,000

technique(s)

indirect ELISA: 1:70,000, quantitative precipitin assay: 3.2-4.8 mg/mL

technique(s)

indirect ELISA: 1:20,000

Descrição geral

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. A immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein. IgG is a major class of immunoglobulin. It consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b and IgG3.

Especificidade

Binds mouse IgG; does not bind other mouse Igs.

Aplicação

Anti-Mouse IgG (Fc specific) antibody produced in goat has been used in enzyme linked immunosorbent assay (ELISA), immunofluorescence analysis/fluorescence activated cell sorting (FACS) analysis.

Ações bioquímicas/fisiológicas

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Outras notas

Antibody adsorbed with human IgG.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Nota de preparo

Adsorbed to reduce background with human samples.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de classe de armazenamento

10 - Combustible liquids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Sjögren's Syndrome (SjS) is a common chronic autoimmune disease characterized by the B cell hyperactivation, lymphocyte infiltration, and tissue damage of exocrine glands. It can also present life-threatening extraglandular manifestations, such as pulmonary and hepatic involvement, renal inflammation and marginal
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Pack SP, et al.
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Human molecular genetics, 22(3), 519-530 (2012-10-27)
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