Merck
All Photos(4)

M3262

Sigma-Aldrich

N-Methyl-D-aspartic acid

≥98% (TLC), solid

Synonym(s):
(R)-2-(Methylamino)succinic acid, NMDA
Empirical Formula (Hill Notation):
C5H9NO4
CAS Number:
Molecular Weight:
147.13
Beilstein:
1724431
Número MDL:
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

teor

≥98% (TLC)

forma

solid

technique(s)

cell culture | mammalian: suitable

cor

white

pf

189-190 °C

application(s)

cell analysis

SMILES string

CN[C@H](CC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1

InChI key

HOKKHZGPKSLGJE-GSVOUGTGSA-N

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Descrição geral

N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.

Aplicação

N-Methyl-D-aspartic acid has been used to induce N-methyl-d-aspartic acid (NMDA) toxicity, cultures of retinal cells were supplemented with NMDA.

Embalagem

25, 100, 250 mg in poly bottle
1, 5 g in poly bottle

Ações bioquímicas/fisiológicas

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
N-Methyl-D-aspartic acid (NMDA) plays a crucial role in release of luteinizing hormone and PRL (prolactin) in the pituitary gland and GnRH (gonadotropin releasing hormone) in the hypothalamus. It acts as a specific agonist for NMDA type glutamate receptors.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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