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M6908

Sigma-Aldrich

Myeloperoxidase from human leukocytes

lyophilized powder, ≥50 units/mg protein

Synonym(s):
MPO, Peroxidase, myelo
CAS Number:
Enzyme Commission number:
Número MDL:
NACRES:
NA.32

fonte biológica

human leucocytes

Nível de qualidade

200

forma

lyophilized powder

specific activity

≥50 units/mg protein

solubilidade

H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)

nº de adesão UniProt

enviado em

dry ice

temperatura de armazenamento

−20°C

Gene Information

human ... MPO(4353)

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Descrição geral

Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.

Aplicação

Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
  • as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
  • as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
  • as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO

Ações bioquímicas/fisiológicas

Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).

Outras notas

Lysosomal heme-containing protein.

Definição da unidade

One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C

forma física

Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride

Nota de análise

Source material tested and found negative for antibody to HIV and for HBSAG.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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Technical Information

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