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N0636

Sigma-Aldrich

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinônimo(s):
Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, Pyridine-3-carboxylic acid amide
Empirical Formula (Hill Notation):
C6H6N2O
Número CAS:
Peso molecular:
122.12
Beilstein:
383619
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

synthetic (organic)

linha de produto

BioReagent

teor

≥98% (HPLC)

forma

powder

peso molecular

Mw 122.12 g/mol

aplicação(ões)

cell culture | insect: suitable
cell culture | mammalian: suitable

cor

white

pf

128-131 °C (lit.)

solubilidade

water: soluble 50 mg/mL, clear, colorless

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

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Categorias relacionadas

Descrição geral

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Aplicação

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Embalagem

100, 500 g in poly bottle

Ações bioquímicas/fisiológicas

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK Alemanha

WGK 1

Ponto de fulgor (ºF)

302.0 °F - closed cup

Ponto de fulgor (ºC)

150 °C - closed cup

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells
Kijima T, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 73-91 (2019)
Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
The influence of nicotinamide on health and disease in the central nervous system
Fricker RA, et al.
International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)
Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors
Romero-Calvo I, et al.
Molecular Cancer Research, molcanres-molca0531 (2018)
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture
Hosic S, et al.
bioRxiv, 400721-400721 (2018)

Artigos

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