Merck
Todas as fotos(2)

N3398

Sigma-Aldrich

S-Nitroso-N-acetyl-DL-penicillamine

≥97%, powder

Todas as fotos(2)
Sinônimo(s):
S-Nitroso-N-acetylpenicillamine, SNAP, N-Acetyl-3-(nitrosothio)-DL-valine
Empirical Formula (Hill Notation):
C7H12N2O4S
Número CAS:
67776-06-1
Peso molecular:
220.25
Número MDL:
MFCD00272624
ID de substância PubChem:
24278584
NACRES:
NA.32

Nível de qualidade

300

teor

≥97%

forma

powder

cor

faint green to very dark green

solubilidade

H2O: ≥2 mg/mL
DMSO: ≥20 mg/mL, clear (faint green to very dark green)

temperatura de armazenamento

−20°C

SMILES string

CC(=O)NC(C(O)=O)C(C)(C)SN=O

InChI

1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)

InChI key

ZIIQCSMRQKCOCT-UHFFFAOYSA-N

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Aplicação

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has been used:
  • as a positive control in nitrite generation assay.
  • to block the activity of endogenous transglutaminase (TG2).
  • in proliferation assays to generate nitric oxide (NO) in cell cultures.

Embalagem

25 mg in poly bottle
50 mg in glass bottle

Ações bioquímicas/fisiológicas

NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase.
SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315 - H319 - H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

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Mais documentos

Structure Search

Quotes and Ordering

Bulk Quote-Order Product
Jodie D Anderson et al.
Journal of veterinary internal medicine, 33(4), 1593-1601 (2019-05-28)
Intravenous continuous rate infusion (IVCRI) of lispro at a starting dose of 0.09 U/kg/h and the use of 0.9% sodium chloride (NaCl) for fluid resuscitation in cats with diabetic ketoacidosis (DKA) have not been reported. Protocols for correction of electrolyte deficiencies
Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.
Eriksson U
Circulation, 103(1), 18-21 (2001)
Immunomodulatory activities of chitin microparticles on Leishmania major-infected murine macrophages.
Dehghani F
Archives of Medical Research, 42(7), 572-576 (2011)
Sophiya Garasia et al.
Scientific reports, 7(1), 1629-1629 (2017-05-11)
We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study.
The redox state of transglutaminase 2 controls arterial remodeling.
van den Akker J
PLoS ONE, 6(8), e23067-e23067 (2011)
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Artigos

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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