Merck
All Photos(2)

P1038

Sigma-Aldrich

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

Synonym(s):
Poly (C,I)
CAS Number:
Número MDL:
NACRES:
NA.51

Nível de qualidade

200

forma

powder

temperatura de armazenamento

−20°C

Aplicação

Poly(cytidylic-inosinic) acid potassium salt has been used:
  • in pretreatment to understand Con A-induced hepatitis in mice[1]
  • in RNA extraction from hemolymph plasma for qPCR detection assay[2]
  • to induce inflammatory changes in liver[3]
  • as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells[4]

Embalagem

5 mg in glass bottle
10 mg in poly bottle

Ações bioquímicas/fisiológicas

Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).
Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC).[3] Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.[1]

Outras notas

Random copolymer

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service