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P215

Sigma-Aldrich

PD 98,059

solid

Sinônimo(s):
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
Empirical Formula (Hill Notation):
C16H13NO3
Número CAS:
Peso molecular:
267.28
Número MDL:
ID de substância PubChem:

Nível de qualidade

100

forma

solid

cor

yellow

solubilidade

DMSO: 10 mg/mL, clear

temperatura de armazenamento

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

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Aplicação

PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
  • in culture medium for cell migration assay

Embalagem

1, 5 mg in glass bottle

Ações bioquímicas/fisiológicas

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Características e benefícios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações legais

Sold with permission of Warner Lambert Company.

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificado de análise

Certificado de origem

Extracellular Matrix Proteins: Advances in Research and Application (2012)
Ki-Sun Park et al.
Nucleic acids research, 45(22), 12766-12779 (2017-12-16)
Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on...
Lingling Zhang et al.
European journal of pharmacology, 792, 15-25 (2016-11-05)
Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been...
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Zeng C, et al.
Journal of Hypertension, 27(5), 1033-1033 (2009)
Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Chen J
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)

Artigos

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EGF Signaling: Tracing Cancer's Path

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