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PD 98,059


2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
Empirical Formula (Hill Notation):
Número CAS:
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ID de substância PubChem:

Nível de qualidade







DMSO: 10 mg/mL, clear

temperatura de armazenamento


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InChI key


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PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
  • in culture medium for cell migration assay


1, 5 mg in glass bottle

Ações bioquímicas/fisiológicas

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Características e benefícios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações legais

Sold with permission of Warner Lambert Company.

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Alemanha


Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificado de análise

Certificado de origem

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Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
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