P4663

Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt 5,000-15,000

Número CAS:
Número MDL:
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.26

forma

powder

Nível de qualidade

200

peso molecular

5,000-15,000

aplicação(ões)

cell analysis: suitable
detection: suitable

cor

white to off-white

temperatura de armazenamento

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

Procurando produtos similares? Visit Guia de comparação de produtos

Categorias relacionadas

Embalagem

10, 50, 100 mg in poly bottle

Qualidade

Contains 3% or less ornithine residue.

Nota de análise

Molecular weight based on viscosity of precursor poly-L-ornithine.

Outras notas

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9...
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 153-160 (2003)
Gitanjali Sharma et al.
Journal of pharmaceutical sciences, 101(7), 2468-2478 (2012-04-21)
We report bifunctional liposomal delivery system, combining transferrin (Tf)-mediated receptor targeting and poly-L-arginine (PR)-facilitated cell penetration, which overcomes the drawback of saturation of delivery. PR was conjugated to the distal end of distearoyl phosphoethanolamine-polyethylene glycol (PEG) 2000 and was incorporated...
Artigos
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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