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P7002

Sigma-Aldrich

Phospho(enol)pyruvic acid trisodium salt hydrate

≥97% (enzymatic)

Sinônimo(s):
PEP, 2-(Phosphonooxy)-2-propenoic acid trisodium salt
Fórmula linear:
C3H2O6PNa3 · x H2O
Número CAS:
Peso molecular:
233.99 (anhydrous basis)
Número MDL:
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

teor

≥97% (enzymatic)

forma

powder

solubilidade

water: 100 mg/mL, clear to slightly hazy, colorless to very faintly yellow

temperatura de armazenamento

−20°C

SMILES string

[Na].OC(=O)C(=C)OP(O)(O)=O

InChI

1S/C3H5O6P.Na.H/c1-2(3(4)5)9-10(6,7)8;;/h1H2,(H,4,5)(H2,6,7,8);;

InChI key

KZPUEZVJSLLABH-UHFFFAOYSA-N

Aplicação

Phospho(enol)pyruvic acid trisodium salt hydrate has been used in:
  • several enzyme activity assays, such as PRPP synthetase (PRPPS) assay, ribokinase (RK) assay, adenine phosphoribosyltransferase (APRT) assay
  • in the reaction mixture for enzyme kinetic assay to determine platelet-derived growth factor receptor α (PDGFRA) kinetic parameters
  • as a component in buffer B to react with adenosine diphosphate (ADP) to form adenosine triphosphate (ATP) for energy charge measurement

Ações bioquímicas/fisiológicas

Phosphoenolpyruvic acid plays a major role in the initial step of glycolysis by acting as an inhibitor of hexokinase, phosphoglucose isomerase, phosphofructokinase and aldolase.
Phospho(enol)pyruvic acid (PEP) is involved in glycolysis and gluconeogenesis. In glycolysis, PEP is metabolized by pyruvate kinase to yield pyruvate. In plants, PEP is involved in the formation of aromatic amino acids as well as in the carbon fixation pathway.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Certificado de origem

Kento Tokuyama et al.
Biotechnology and bioengineering, 115(6), 1542-1551 (2018-02-20)
Gene deletion strategies using flux balance analysis (FBA) have improved the growth-coupled production of various compounds. However, the productivities were often below the expectation because the cells failed to adapt to these genetic perturbations. Here, we demonstrate the productivity of...
Structural and biochemical studies of the PDGFRA kinase domain
Liang L, et al.
Biochemical and Biophysical Research Communications, 477(4), 667-672 (2016)
Casimir Ledoux Sofeu et al.
PLoS neglected tropical diseases, 12(9), e0006597-e0006597 (2018-09-07)
Canine rabies is endemic in Cameroon, but human rabies exposures and cases are likely underreported because of inadequate surveillance. In 2014, the surveillance network in the West region of Cameroon was reinforced by introducing a new anti-rabies center, a framework...
Energy metabolic state in hypothermically stored boar spermatozoa using a revised protocol for efficient ATP extraction
Nguyen QT, et al.
Biology Open, 5(11), 1743-1751 (2016)
Timothy R Rudd et al.
Faraday discussions, 218(0), 303-316 (2019-05-28)
A biological medicine (or biologicals) is a term for a medicinal compound that is derived from a living organism. By their very nature, they are complex and often heterogeneous in structure, composition and biological activity. Some of the oldest pharmaceutical...

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