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greener alternative

≥98% (HPLC), powder

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Empirical Formula (Hill Notation):
C22H29N7O5 · 2HCl
Número CAS:
Peso molecular:
Número EC:
Número MDL:
ID de substância PubChem:

Nível de qualidade


≥98% (HPLC)



pontuação do produto alternativo mais ecológico

old score: 88
new score: 79
Find out more about DOZN™ Scoring

características do produto alternativo mais ecológico

Atom Economy
Design for Energy Efficiency
Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.


H2O: 50 mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at −20 °C.)

espectro de atividade do antibiótico

Gram-positive bacteria

categoria alternativa mais ecológica

Modo de ação

protein synthesis | interferes

temperatura de armazenamento


SMILES string




InChI key


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Este Item
Puromycin dihydrochloride Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H2O, suitable for cell culture



Puromycin dihydrochloride










H2O: 50 mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at −20 °C.)


H2O: soluble 50 mg/mL, clear, colorless to faintly yellow


H2O: soluble 10 mg/mL



storage temp.


storage temp.


storage temp.


storage temp.


Quality Level


Quality Level


Quality Level


Quality Level


greener alternative product score

old score: 88
new score: 79
Find out more about DOZN™ Scoring

greener alternative product score

old score: 88
new score: 79
Find out more about DOZN™ Scoring

greener alternative product score


greener alternative product score


Descrição geral

Chemical structure: peptidyl nucleoside
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Atom Economy”, “Design for Energy Efficiency”, “Use of Renewable Feedstock” and “Design for Degradation”. Click here to view its DOZN scorecard.


Recommended for use as a selection agent at a range of 1-10 μg/mL.

Ações bioquímicas/fisiológicas

Puromycin dihydrochloride is a part of the amino-nucleoside family of antibiotics and is derived from Streptomyces alboniger. It is a broad spectrum antibiotic with antitumor activity, as an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation. The recommended working concentration in eukaryotic cell culture is 1-10 μg/mL.
Modo de ação: A puromicina inibe a síntese de proteínas ao causar a terminação precoce de cadeia, agindo como um análogo da extremidade 3′-terminal do aminoacil-tRNA.

Modo de resistência: O gene da puromicina acetil transferase é um gene de resistência efetivo.

Espectro da ação antimicrobiana: Este produto é ativo contra microrganismos gram positivos, menos ativo contra bacilos álcool-ácido resistentes e mais fracamente ativo contra microrganismos gram negativos. A puromicina pode prevenir o crescimento de bactérias, protozoários, algas e células de mamíferos e age rapidamente, matando 99% das células em 2 dias.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at


As supplied, this product remains active for four years when stored at -20°C.

Nota de preparo

This product is soluble in water at 50 mg/mL. A stock solution should be prepared by filtration using a 0.22 μm filter and then stored in aliquots at -20°C. This product is also soluble in methanol at 10 mg/mL.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place


Exclamation mark

Palavra indicadora


Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)


Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Robert J Huber et al.
Biochimica et biophysica acta, 1833(1), 11-20 (2012-10-16)
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that has been implicated in a number of cellular processes. In Dictyostelium, Cdk5 localizes to the nucleus and cytoplasm, interacts with puromycin-sensitive aminopeptidase A (PsaA), and regulates endocytosis, secretion, growth, and multicellular
Claudia Fritsch et al.
Genome research, 22(11), 2208-2218 (2012-08-11)
So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells to generate a transcriptome-wide map of TISs in a human monocytic cell line. A
Robert A J Signer et al.
Nature, 509(7498), 49-54 (2014-03-29)
Many aspects of cellular physiology remain unstudied in somatic stem cells, for example, there are almost no data on protein synthesis in any somatic stem cell. Here we set out to compare protein synthesis in haematopoietic stem cells (HSCs) and
Shingo Ueno et al.
Journal of biotechnology, 162(2-3), 299-302 (2012-09-25)
cDNA display using a puromycin-linker to covalently bridge a protein and its coding cDNA is a stable and efficient in vitro protein selection method. The optimal design of the often-used puromycin-linker is vital for effective selection. In this report, an
Antonina J Kruppa et al.
Biochimica et biophysica acta, 1832(12), 2115-2126 (2013-08-06)
The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent


Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.

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