P9767

Sigma-Aldrich

Sodium palmitate

≥98.5%

Sinônimo(s):
Hexadecanoic acid sodium salt, Palmitic acid sodium salt
Fórmula linear:
CH3(CH2)14COONa
Número CAS:
Peso molecular:
278.41
Beilstein/REAXYS Number:
3575882
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.25

Nível de qualidade

200

fonte biológica

plant (palm)

teor

≥98.5%

forma

powder

pf

283-290 °C (lit.)

grupo funcional

ester

enviado em

ambient

temperatura de armazenamento

2-8°C

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

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Categorias relacionadas

Aplicação

Sodium palmitate (PA) has been used:
  • to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
  • to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
  • as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Embalagem

5, 10, 50 g in poly bottle

Ações bioquímicas/fisiológicas

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

storage_class_code

11 - Combustible Solids

WGK Alemanha

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I dissolve Sodium palmitate, Product P9767?

    We test the solubility in methanol at 50 mg/mL.

  4. How do I dissolve Sodium palmitate, Product P9767?

    Sodium palmitate does not dissolve readily in methanol at room temperature.  We test the solubility by heating it for up to 15 minutes to get a clear, colorless solution. Note that the boiling point of methanol is approximately 65°C.

  5. How do I store Sodium palmitate, Product P9767, as provided?

    This compound is stable for years at 2-8°C.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Chemical composition of everyday products (2005)
Nicolas J Pillon et al.
Cell communication and signaling : CCS, 10(1), 30-30 (2012-10-20)
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of cytokines which in turn impact on the surrounding tissue. However...
Hepatitis B virus X protein induces hepatic steatosis by enhancing the expression of liver fatty acid binding protein
Wu Y, et al.
Journal of Virology, 90(4), 1729-1740 (2016)
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
Linnéa Eriksson et al.
Cardiovascular diabetology, 11, 27-27 (2012-03-23)
The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early event in the pathogenesis of atherogenesis and cardiovascular...
Artigos
Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are synthesized by the cell.
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