PLA0185

Sigma-Aldrich

Rabbit anti-BRCA1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Sinônimo(s):
complementation group S, regulatory subunit 53, truncated breast cancer type 1 susceptibility protein, breast cancer 1, early onset, truncated BRCA1, breast and ovarian cancer sususceptibility protein 1, BRCC1, RING finger protein 53, truncated breast and ovarian cancer sususceptibility protein 1, Fanconi anemia, RNF53, early onset breast cancer 1, truncated breast and ovarian cancer susceptibility protein 1, FANCS, PNCA4, protein phosphatase 1, BRCAI, BRCA1/BRCA2-containing complex, PSCP, breast and ovarian cancer susceptibility protein 1, IRIS, BROVCA1, subunit 1, PPP1R53
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity purified immunoglobulin

antibody product type

primary antibodies

grau

Powered by Bethyl Laboratories, Inc.

species reactivity

human

concentração

1 mg/mL

aplicação(ões)

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:500- 1:2,500

nº de adesão

NP_009225.1

nº de adesão UniProt

enviado em

wet ice

temperatura de armazenamento

2-8°C

Gene Information

rabbit ... BRCA1(672)

Imunogênio

The epitope recognized by PLA0185 maps to a region between residue 250 and 300 of human breast cancer 1 using the numbering given in entry NP_009225.1 (GeneID 672).

forma física

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Outras notas

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Alemanha

nwg

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise

Certificado de origem

Feng Bai et al.
Cancer research, 74(21), 6161-6172 (2014-09-23)
BRCA1 mutation carriers are predisposed to developing basal-like breast cancers with high metastasis and poor prognosis. Yet, how BRCA1 suppresses formation of basal-like breast cancers is still obscure. Deletion of p18(Ink4c) (p18), an inhibitor of CDK4 and CDK6, functionally inactivates...
Bárbara Alcaraz Silva et al.
The Journal of biological chemistry, 289(33), 22771-22784 (2014-07-02)
Chromosome ends contain nucleoprotein structures known as telomeres. Damage to chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell cycle arrest. However, little is known regarding the signaling from damaged chromosome ends (designated here as "TIPs")...
Qing Xia et al.
International journal of oncology, 44(3), 735-744 (2014-01-01)
Breast cancer is one of the most common malignancies in women. Approximately 15% of the patients belong to the triple-negative breast cancer (TNBC) group, and have the disadvantage of not benefiting from currently available receptor-targeted systemic therapies. Some cancers in...

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