Merck
All Photos(2)

PLA0199

Sigma-Aldrich

Rabbit anti-Vimentin Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
CTRCT30, HEL113, epididymis luminal protein 113
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity purified immunoglobulin

antibody product type

primary antibodies

grau

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

technique(s)

immunohistochemistry: 1:200-1:1,000
western blot: 1:2,000- 1:10,000

nº de adesão

NP_003371.2

enviado em

wet ice

temperatura de armazenamento

2-8°C

Gene Information

rabbit ... Vimentin(7431)

Descrição geral

Vimentin is a specific type III intermediate filament (IF) protein.[1][2] It is abundantly expressed in mesenchymal cells.[1][3] The gene encoding this protein is localized on human chromosome 10p13.[4]

Imunogênio

The epitope recognized by PLA0199 maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).

Ações bioquímicas/fisiológicas

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer.[3][2] It also controls infectious internalization of human papillomavirus 16 pseudovirions.[2]

forma física

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Outras notas

Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de classe de armazenamento

12 - Non Combustible Liquids

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service