PZ0005

Voriconazole

≥98% (HPLC)

• Synonym(s): 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496
• Empirical Formula (Hill Notation): C₁₆H₁₄F₃N₅O
• CAS Number: 137234-62-9
• Molecular Weight: 349.31
• Número MDL: MFCD00905717
• ID de substância PubChem: 329823674
• NACRES: NA.77

Properties

• Nível de qualidade: 100
• teor: ≥98% (HPLC)
• forma: powder
• manufacturer/tradename: Pfizer^®
• cor: white
• solubilidade: DMSO: >20 mg/mL
• originador: Pfizer
• temperatura de armazenamento: room temp
• SMILES string: C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
• InChI key: BCEHBSKCWLPMDN-MGPLVRAMSA-N

Description

Descrição geral

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Aplicação

Voriconazole has been used:

• as a control and Erg11 inhibitor in YPD medium
• as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
• as an antifungal agent to test its interactions with valproic acid (VPA)
• to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Embalagem

5 mg in glass bottle

25 mg in poly bottle

Ações bioquímicas/fisiológicas

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Outras notas

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações legais

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety Information

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301 - H341 - H351 - H361 - H371 - H372 - H373 - H412
• Declarações de precaução: P201 - P202 - P260 - P264 - P273 - P301 + P310
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
• Órgãos-alvo: Eyes
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable