Merck
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S6883

Sigma-Aldrich

Substance P acetate salt hydrate

≥95% (HPLC), powder

Empirical Formula (Hill Notation):
C63H98N18O13S · xC2H4O2 · yH2O
Número CAS:
Peso molecular:
1347.63 (anhydrous free base basis)
Beilstein:
5153552
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

teor

≥95% (HPLC)

forma

powder

peso molecular

1348 Da by calculation (Average Mass)

cor

white

solubilidade

0.1 M acetic acid: 1 mg/mL

nº de adesão UniProt

temperatura de armazenamento

−20°C

SMILES string

[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1

InChI key

VHKFRLDSEZYWAC-CIYRQLMPSA-N

Gene Information

human ... TAC1(6863)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Descrição geral

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Aplicação

Substance P acetate salt hydrate has been:
  • used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
  • administered in central nucleus (ACE) in rat to study its positive reinforcing effects
  • used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Substance P acetate salt hydrate has been used in competition binding assays.

Ações bioquímicas/fisiológicas

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

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Certificado de origem

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Product Information Sheet

Mais documentos

Quotes and Ordering

D G Snijdelaar et al.
European journal of pain (London, England), 4(2), 121-135 (2000-08-25)
Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the
G F Joos et al.
Allergy, 55(4), 321-337 (2000-04-27)
The sensory neuropeptides substance P (SP) and neurokinin A (NKA) are localized to sensory airway nerves, from which they can be released by a variety of stimuli, including allergen, ozone, or inflammatory mediators. Sensory nerves containing these peptides are relatively
Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt
Sikandar S, et al.
The European Journal of Neuroscience, 44(1), 1714-1722 (2016)
The effect of capsaicin on substance P expression in pulp tissue inflammation.
Caviedes-Bucheli J
International Endodontic Journal, 38(1), 30-33 (2005)
Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference
Kertes, E, et al.
Behavioural Brain Research, 215(1), 152-155 (2010)

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