Merck
Todas as fotos(1)

S6883

Sigma-Aldrich

Substance P acetate salt hydrate

≥95% (HPLC), powder

Empirical Formula (Hill Notation):
C63H98N18O13S · xC2H4O2 · yH2O
Número CAS:
Peso molecular:
1347.63 (anhydrous free base basis)
Beilstein:
5153552
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

Ensaio

≥95% (HPLC)

forma

powder

peso molecular

1348 Da by calculation (Average Mass)

condição de armazenamento

(Keep container tightly closed in a dry and well-ventilated place.)

cor

white

solubilidade

0.1 M acetic acid: 1 mg/mL

nº de adesão UniProt

temperatura de armazenamento

−20°C

SMILES string

[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1

InChI key

VHKFRLDSEZYWAC-CIYRQLMPSA-N

Gene Information

human ... TAC1(6863)

Procurando produtos similares? Visit Guia de comparação de produtos

Comparar Itens Semelhantes

Ver Comparação Total

Show Differences

1 of 4

Este Item
M6638SML0934V9879
Substance P acetate salt hydrate ≥95% (HPLC), powder

Sigma-Aldrich

S6883

Substance P acetate salt hydrate

[Met5]Enkephalin acetate salt hydrate ≥95.0% (HPLC), powder

Sigma-Aldrich

M6638

[Met5]Enkephalin acetate salt hydrate

Sigma-Aldrich

Sigma-Aldrich

SML0934

Enfuvirtide acetate salt

[Arg8]-Vasopressin acetate salt ≥95% (HPLC)

Sigma-Aldrich

V9879

[Arg8]-Vasopressin acetate salt

form

powder

form

powder

form

powder

form

powder

mol wt

1348 Da by calculation (Average Mass)

mol wt

-

mol wt

-

mol wt

-

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

storage condition

-

storage condition

desiccated, protect from light

storage condition

-

color

white

color

white

color

white to off-white

color

-

solubility

0.1 M acetic acid: 1 mg/mL

solubility

-

solubility

-

solubility

water: 20.0-20.8 mg/mL, clear, colorless to faintly yellow

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Descrição geral

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Aplicação

Substance P acetate salt hydrate has been:

  • used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
  • administered in central nucleus (ACE) in rat to study its positive reinforcing effects
  • used in competition binding assays
  • used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Ações bioquímicas/fisiológicas

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Os números dos produtos são combinados com os tamanhos/quantidades da embalagem quando exibidos no site (exemplo: T1503-25G). Por favor, certifique-se você insere APENAS o número do produto no campo Número do produto (Exemplo T1503).

Exemplo

T1503
Número do produto
-
25G
Tamanho/quantidade da embalagem

Exemplos adicionais:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

insira como1.000309185)

Está com problemas? Sinta-se à vontade para entrar em contato Assistência Técnica para obter assistência

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Produtos Aldrich

  • Se encontrar um número de lote como TO09019TO - insira o número do lote 09019TO sem as duas primeiras letras.

  • Se encontrar um número de lote com um código de preenchimento, como 05427ES-021 - insira o número do lote 05427ES sem o código de preenchimento -021.

  • Se encontrar um número de lote com um código de preenchimento como STBB0728K9 - digite o número do lote STBB0728 sem o código de preenchimento K9.

Não encontra o que está procurando?

Em alguns casos, um COA pode não estar disponível on-line. Se a sua pesquisa não encontrou o COA, você pode solicitar um.

Solicitar COA

Os clientes também visualizaram

Slide 1 of 6

1 of 6

Sigma-Aldrich

Sigma-Aldrich

SCP0241

Spantide II

β-Endorphin human ≥95% (HPLC)

Sigma-Aldrich

E6261

β-Endorphin human

Sigma-Aldrich

Sigma-Aldrich

C0292

Calcitonin Gene Related Peptide rat

Sigma-Aldrich

Sigma-Aldrich

C0167

Calcitonin Gene Related Peptide human

Bradykinin acetate salt powder, ≥98% (HPLC)

Sigma-Aldrich

B3259

Bradykinin acetate salt

Neurokinin B ≥95% (HPLC)

Sigma-Aldrich

N4143

Neurokinin B

Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference
Kertes, E, et al.
Behavioural Brain Research, 215(1), 152-155 (2010)
The role of substance P in inflammatory disease.
O'Connor TM
Journal of Cellular Physiology, 201(2), 167-180 (2004)
Wei Wang et al.
American journal of physiology. Heart and circulatory physiology, 297(2), H726-H734 (2009-06-16)
Muscular lymphatics use both phasic and tonic contractions to transport lymph for conducting their vital functions. The molecular mechanisms regulating lymphatic muscle contractions are not well understood. Based on the well-established finding that the phosphorylation of myosin light chain 20
Eliska Mistrova et al.
Neuropeptides, 58, 41-51 (2015-12-27)
This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions
Erika Kertes et al.
Behavioural brain research, 205(1), 307-310 (2009-06-27)
Substance P (SP) can have positive reinforcing or aversive properties, depending on the dose used and the site of action in the brain. Experimental findings suggest that the amygdala is involved in reward-related processes. The presence of SP-immunoreactive fibers and

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica