Merck
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S8160

Sigma-Aldrich

Superoxide Dismutase from bovine liver

lyophilized powder, ≥1500 units/mg protein

Synonym(s):
SOD, Superoxide: superoxide oxidoreductase
CAS Number:
Enzyme Commission number:
Número EC:
Número MDL:
NACRES:
NA.54

forma

lyophilized powder

Nível de qualidade

200

specific activity

≥1500 units/mg protein

peso molecular

32.5 kDa

composição

Protein, ≥70% biuret

nº de adesão UniProt

temperatura de armazenamento

−20°C

Gene Information

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Descrição geral

Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.

Aplicação

Superoxide dismutase from bovine liver has been used in a study to determine that hypercholesterolemia increases endothelial superoxide anion production. Superoxide dismutase from bovine liver has also been used in a study to investigate diazo coupling, subunit interactions and electrophoretic variants of bovine erythrocyte superoxide dismutase.

Embalagem

15000, 30000, 75000 units in poly bottle

Ações bioquímicas/fisiológicas

Catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.

Definição da unidade

One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.

forma física

Lyophilized powder containing potassium phosphate buffer salts

Nota de análise

For assay method, see McCord, J.M. and Fridovich, I., J. Biol. Chem., 244, 6049 (1969).

Código de classe de armazenamento

12 - Non Combustible Liquids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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