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SAB4300334
Anti-AKT1 (Ab-473) antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
Anti-v-akt murine thymoma viral oncogene homolog 1 antibody produced in rabbit, Anti-PKB antibody produced in rabbit, Anti-AKT antibody produced in rabbit, Anti-MGC99656 antibody produced in rabbit, Anti-PKB-ALPHA antibody produced in rabbit
Número MDL:
NACRES:
NA.41
fonte biológica
rabbit
Nível de qualidade
100
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
~60 kDa
species reactivity
human, mouse
concentração
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
Isotipo
IgG
sequência de imunogênio
(Q-F-S-Y-S)
nº de adesão NCBI
nº de adesão UniProt
enviado em
wet ice
temperatura de armazenamento
−20°C
Gene Information
human ... AKT1(207)
Descrição geral
AKT1 (AKT serine/threonine kinase 1) is also called as v-akt murine thymoma viral oncogene homolog 1 and PKBα (protein kinase B). It is upregulated in liver, muscle and adipocytes. AKT1 gene is mapped to chromosome 14q32. It is a member of AKT family that has an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
Imunogênio
Peptide sequence around aa. 471-475 (Q-F-S-Y-S), according to the protein AKT1.
Aplicação
Anti-AKT1 (Ab-473) antibody has been used in western blot analysis.
Ações bioquímicas/fisiológicas
AKT1 (AKT serine/threonine kinase 1) controls the survival of cell and anti-apoptotic actions that attack the pathogenesis of several cancers, hence it plays a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development.
Características e benefícios
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Descrição-alvo
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
forma física
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
10 - Combustible liquids
WGK
WGK 1
Ponto de fulgor (ºF)
Not applicable
Ponto de fulgor (ºC)
Not applicable
Certificate of Analysis
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Certificate of Origin
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