SMB00388

2,4,3′,5′-tetramethoxystilbene

≥98% (HPLC)

• Synonym(s): 2,4,3′,5′-tetramethoxystilbene, 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene, 2,3′,4,5′-Tetramethoxystilbene
• Empirical Formula (Hill Notation): C₁₈H₂₀O₄
• CAS Number: 24144-92-1
• Molecular Weight: 300.35
• Número MDL: MFCD03428621
• ID de substância PubChem: 329824983
• NACRES: NA.79

Properties

• Nível de qualidade: 200
• teor: ≥98% (HPLC)
• forma: powder
• technique(s): HPLC: suitable
• cor: white to yellow
• temperatura de armazenamento: −20°C
• SMILES string: COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
• InChI: 1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
• InChI key: JDBCWSHYEQUBLW-AATRIKPKSA-N

Description

Embalagem

10 mg in glass bottle

50 mg in poly bottle

Ações bioquímicas/fisiológicas

2,3′,4,5′-Tetramethoxystilbene, also known as TMS, is a selective and competitive inhibitor of cytochrome P450 1B. It is a synthetic trans-stilbene analog. TMS is an analog of resveratrol and is an anti-cancer agent. TMS is cytotoxic to gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. It binds to sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) and promotes apoptosis and autophagy. TMS is also a selective inhibitor of CYP1B1.

Safety Information

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 13 - Non Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable