Merck
All Photos(3)

SML0196

Sigma-Aldrich

Resiquimod

≥98% (HPLC)

Synonym(s):
4-Amino-2-(ethoxymethyl)-alpha, R-848, R848, S28463, alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
Empirical Formula (Hill Notation):
C17H22N4O2
CAS Number:
Molecular Weight:
314.38
Número MDL:
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

100

teor

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated
protect from light

cor

white to tan

solubilidade

DMSO: 10 mg/mL, clear (warmed to 60 °C)

enviado em

wet ice

temperatura de armazenamento

−20°C

SMILES string

CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O

InChI

1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)

InChI key

BXNMTOQRYBFHNZ-UHFFFAOYSA-N

Aplicação

Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation([1] and B cells.[2] It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.[3][4]
Resiquimod may be used in immunological and cancer-related cell signaling studies.

Embalagem

10, 50 mg in glass bottle

Ações bioquímicas/fisiológicas

Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities.
Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.[5][6]
Resiquimod is 314.4 Da molecule which elicits immune function during visceral infection with L. infantum Sp. It mediates the trafficking of granulocytes, macrophages, leukocytes and dendritic cells.[7] It is a recommended topical drug for treating skin tumors like actinic keratosis (AK) and superficial basal cell carcinoma.[8]

Características e benefícios

This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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