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SML0445

Sigma-Aldrich

Clemastine fumarate salt

≥98% (HPLC)

Synonym(s):
(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
Empirical Formula (Hill Notation):
C21H26ClNO · C4H4O4
CAS Number:
Molecular Weight:
459.96
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

100

teor

≥98% (HPLC)

forma

powder

atividade óptica

[α]/D +15 to +25°, c = 1 in methanol

condição de armazenamento

desiccated

cor

white to beige

solubilidade

DMSO: 5 mg/mL (clear solution; warmed)

temperatura de armazenamento

room temp

SMILES string

OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChI key

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

Gene Information

human ... HRH1(3269)

Descrição geral

Clemastine fumarate is used to treat multiple sclerosis,[1] sneezing and rhinorrhea linked to common cold.[2] It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.[1]

Aplicação

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.[3]

Embalagem

100 mg in glass bottle

Ações bioquímicas/fisiológicas

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Características e benefícios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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