Merck
  • SML2531
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SML2531

Sigma-Aldrich

TH5487

≥98% (HPLC)

Synonym(s):
4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide
Empirical Formula (Hill Notation):
C19H18BrIN4O2
CAS Number:
Molecular Weight:
541.18

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

2-8°C

SMILES string

IC1=CC=C(NC(N2CCC(N(C3=CC=CC(Br)=C3N4)C4=O)CC2)=O)C=C1

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TH5487 ≥98% (HPLC)

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SML2531

TH5487

TH1760 ≥98% (HPLC)

Sigma-Aldrich

SML3019

TH1760

TH-257 ≥98% (HPLC)

Sigma-Aldrich

SML2275

TH-257

TH1020 ≥95% (HPLC)

Sigma-Aldrich

SML1741

TH1020

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Ações bioquímicas/fisiológicas

TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG1-dependent proinflammatory gene expression by binding in the OGG1 active site, preventing OGG1 from engaging damaged DNA in vitro and in cells, resulting in decreased proinflammatory gene expression.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable


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