SRE0053

Sigma-Aldrich

Lysostaphin from Staphylococcus staphylolyticus

Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

Sinônimo(s):
Glycyl-glycine Endopeptidase
Número CAS:
Número da licença da enzima:
Número MDL:
NACRES:
NA.32

Nível de qualidade

400

forma

lyophilized powder

specific activity

≥500 units/mg protein

peso molecular

26,926 Da

composição

protein, 50-70% biuret

embalagem

pkg of (package size sold on basis of mg protein)

enviado em

wet ice

temperatura de armazenamento

−20°C

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Descrição geral

Lysostaphin is a glycylglycine endopeptidase. It is an important antibacterial enzyme.

Ações bioquímicas/fisiológicas

Lysostaphin has the ability to cleave both viable and heat-killed S. aureus cells. It is one of the major antibacterial agents for the staphylococci. Lysostaphin cleaves the cross-linking pentaglycine bridges in the cell walls of staphylococci. Thus it is considered as an antistaphylococcal therapeutic agent.
Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

Definição da unidade

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH7.5 at 37°C in a 6.0ml reaction mixture.

storage_class_code

13 - Non Combustible Solids

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise

Certificado de origem

Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces
Wu J A, et al.
Antimicrobial Agents and Chemotherapy, 47(11), 3407-3414 (2003)
Lysostaphin: a new bacteriolytic agent for the Staphylococcus
Schindler, Ch A and Schuhardt, VT
Proceedings of the National Academy of Sciences of the USA, 51(3), 414-421 (1964)

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