Merck
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SRP4915

Sigma-Aldrich

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonym(s):
OL-64, Visceral adipose tissue- derived serine protease inhibitor, Serpin A12 precursor, Vaspin, Visceral adipose-specific serpin, SERPINA12
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in E. coli

teor

≥90% (HPLC)
≥90% (SDS-PAGE)

forma

lyophilized powder

peso molecular

~47.0 kDa

embalagem

pkg of 25 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

endotoxin, tested

nº de adesão NCBI

enviado em

dry ice

temperatura de armazenamento

−70°C

Gene Information

human ... SPA12(145264)

Descrição geral

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

Ações bioquímicas/fisiológicas

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

forma física

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

nwg

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Certificate of Origin

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