T1126

Sigma-Aldrich

Thyroglobulin from porcine thyroid gland

powder

Número CAS:
Número EC:
Número MDL:
NACRES:
NA.61

Nível de qualidade

200

fonte biológica

Porcine thyroid

forma

powder

peso molecular

~670 kDa

composição

Iodine, ≥0.3%

análise de nitrogênio

14.0-17.5% total

aplicação(ões)

protein purification: suitable

cinzas

≤4%

pI 

4.58

temperatura de armazenamento

−20°C

Gene Information

pig ... TG(100156471)

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Embalagem

100, 500 mg in poly bottle
1 g in poly bottle

Ações bioquímicas/fisiológicas

Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.

Outras notas

Electrophoretically heterogeneous.

Nota de preparo

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise
Certificado de origem
Sanathana Konugolu Venkata Sekar et al.
Scientific reports, 8(1), 10015-10015 (2018-07-04)
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents...
L D Kohn et al.
Trends in endocrinology and metabolism: TEM, 12(1), 10-16 (2001-01-04)
Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as an apical porter and shows that follicular thyroglobulin is a transcriptional regulator of...
Stine L Andersen et al.
European journal of endocrinology, 168(5), 723-731 (2013-02-28)
Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate...
Andrew N Hoofnagle et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1343-1352 (2013-03-02)
Serum thyroglobulin (Tg) measurements are central to the management of patients treated for differentiated thyroid carcinoma. For decades, Tg measurements have relied on methods that are subject to interference by commonly found substances in human serum and plasma, such as...
Mark M Kushnir et al.
Clinical chemistry, 59(6), 982-990 (2013-02-12)
Measurement of serum thyroglobulin (Tg) is used to monitor patients after treatment for differentiated thyroid carcinoma (TC). Difficulty in using Tg as a biomarker of the recurrence of TC in many patients stems from the presence of endogenous anti-Tg autoantibodies...
Artigos
With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
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