T2877

3,3′,5-Triiodo-L-thyronine

≥95% (HPLC), powder

• Synonym(s): O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• Empirical Formula (Hill Notation): C₁₅H₁₂I₃NO₄
• CAS Number: 6893-02-3
• Molecular Weight: 650.97
• Beilstein: 2710227
• Número EC: 229-999-3
• Número MDL: MFCD00002593
• ID de substância PubChem: 24900088
• NACRES: NA.32

Properties

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• sterility: non-sterile
• teor: ≥95% (HPLC)
• forma: powder
• atividade óptica: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• technique(s): transfection: suitable
• pf: 234-238 °C (lit.)
• solubilidade: 4 M NH₄OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
• enviado em: ambient
• temperatura de armazenamento: −20°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChI key: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Description

Aplicação

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.

Embalagem

100, 250, 500 mg in poly bottle

1, 5 g in poly bottle

Ações bioquímicas/fisiológicas

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

Nota de preparo

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

Safety Information

• Código de classe de armazenamento: 13 - Non Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves